Loss of Tet2 affects platelet function but not coagulation in mice
نویسندگان
چکیده
منابع مشابه
Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice.
TET1/2/3 are methylcytosine dioxygenases that regulate cytosine hydroxymethylation. Tet1/2 are abundantly expressed in HSC/HPCs and are implicated in hematological malignancies. Tet2 deletion in mice causes myeloid malignancies, while Tet1-null mice develop B cell lymphoma after an extended period of latency. Interestingly, TET1/2 are often concomitantly downregulated in acute B-lymphocytic leu...
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15 صفحه اولPappa2 deletion in mice affects male but not female fertility
BACKGROUND Recent studies have found associations between the gene encoding pregnancy associated plasma protein-A2 (PAPP-A2), a protease of insulin-like growth factor binding protein -5 (IGFBP-5), and measures of female reproductive performance in cattle. The purpose of the present study was to test the effects of Pappa2 deletion on reproduction in mice. FINDINGS We measured the fertility and...
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ژورنال
عنوان ژورنال: Blood Science
سال: 2020
ISSN: 2543-6368
DOI: 10.1097/bs9.0000000000000055